The articles assist in the understanding of the anatomy involved in treating specific conditions and performing procedures. More than 100 anatomy articles feature clinical images and diagrams of the human body's major systems and organs. More than 1000 clinical procedure articles provide clear, step-by-step instructions and include instructional videos and images to allow clinicians to master the newest techniques or to improve their skills in procedures they have performed previously. Topics are richly illustrated with more than 40,000 clinical photos, videos, diagrams, and radiographic images. More than 6000 evidence-based and physician-reviewed disease and condition articles are organized to rapidly and comprehensively answer clinical questions and to provide in-depth information in support of diagnosis, treatment, and other clinical decision-making. The topics provided are comprehensive and span more than 30 medical specialties, covering: Diseases and Conditions The clinical information represents the expertise and practical knowledge of top physicians and pharmacists from leading academic medical centers in the United States and worldwide.
An Australian (1995) study found oxazepam less toxic and less sedative, and temazepam more toxic and more sedative, than most benzodiazepines in overdose.Medscape's clinical reference is the most authoritative and accessible point-of-care medical reference for physicians and healthcare professionals, available online and via all major mobile devices. Temazepam was shown to be more toxic than the majority of benzodiazepines. Over 10 years in the United Kingdom, 1512 fatal poisonings have been attributed to benzodiazepines with or without alcohol. Benzodiazepines are one of the most highly prescribed classes of drugs, and they are commonly used in self-poisoning.
The US Food and Drug Administration (FDA) has subsequently issued a black box warning regarding concurrent use of benzodiazepines and opioids. In 2013, benzodiazepines were involved in 31% of the estimated 22,767 deaths from prescription drug overdose in the United States. However, combinations of high doses of benzodiazepines with alcohol, barbiturates, opioids or tricyclic antidepressants are particularly dangerous, and may lead to severe complications such as coma or death. Deaths from single-drug benzodiazepine overdoses occur infrequently, particularly after the point of hospital admission.
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